Articles for category "Media Release"


21 October 2017 · Applied research · Media Release

Building New Moss Factories

Moss cells like these in an Erlenmeyer-flask are able to serve as environmentally friendly and fast molecule factories. Photo: Sigrid Gombert, Freiburg

The new EU project MossTech will promote the environmentally friendly production of complex molecules for medicine and industry. In this project, coordinated by Technical University of Denmark in Copenhagen, Prof. Dr. Ralf Reski from the University of Freiburg, Germany, will be further developing a variety of mosses as sustainable and fast-growing molecule factories. As an EU-designated Innovative Training Network (ITN), the project will receive €1.6 million from the EU over the next four years as part of its Horizon 2020 program. Two out of the six PhD students involved in the MossTech project will spend a year at the University of Freiburg learning these methods and will continue for another two years with industrial partners in Denmark or Italy, respectively. The goal is to apply these methods to mosses that have not yet been researched in the hopes of cheaply and safely producing complex fine chemicals in genetically modified mosses.

media release at the University of Freiburg

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19 October 2017 · Applied research · Media Release

Phase 1 clinical trials with moss-aGal successfully completed

Greenovation Biotech GmbH announced the completion of its Phase 1 moss-aGal study to combat Fabry disease (FD). The Phase I study was designed as a single dose administered in six patients suffering from FD, a rare metabolic disease belonging to the group of inherited lysosomal storage diseases. Patients were monitored over 28 days. Primary endpoints were safety and pharmacokinetics. The single dose of moss-aGal was well tolerated by patients. Moss-aGal is the first clinical product produced in Greenovation`s moss-based technology and therefore the first ever moss-made drug candidate tested in humans. The privately owned company Greenovation was founded by Prof. Dr. Ralf Reski and Prof. Dr. Gunter Neuhaus in 1999. Moss-aGal is a recombinant form of human alpha-galactosidase produced in moss to treat Fabry patients with enzyme replacement therapy (ERT).

whole media release at Greenovation

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20 June 2017 · Applied research · Media Release

Additional center for moss-aGal phase I clinical trial

Greenovation Biotech GmbH announced opening of an additional clinical study center in Hungary for its phase I clinical trial to test moss-aGal last week. Moss-aGal is a recombinant form of human alpha-galactosidase produced in moss to treat Fabry patients with enzyme replacement therapy (ERT). Founded by Prof. Dr. Ralf Reski and Prof. Dr. Gunter Neuhaus, the company Greenovation also reports that the first three patients have already been treated with moss-aGal at the University Medical Center in Mainz, Germany. They received a single dose of moss-aGal and no side effects have been reported. With the new Hungarian center, the clinical study with six patients is expected to be completed within this year. In phase I safety, pharmacokinetics and efficacy of moss-aGal are evaluated. Morbus Fabry is a metabolic disease belonging to the group of inherited lysosomal storage diseases. Patients with this rare disease often do not have access to treatment.

whole media release at Greenovation

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16 May 2017 · Applied research · Media Release

Moss Saves Moorlands

Traditional peat mining destroys moorlands. Photo: Ralf Reski

Peat moss shall be developed as a sustainable and renewable alternative as part of the "MOOSzucht" (moss cultivation) project to invent a renewable resource for peat extraction and to protect climate in the long run. Professor Dr. Ralf Reski and Dr. Eva Decker from the University of Freiburg, Germany, participate in the project under the leadership of scientists from Greifswald to contribute their knowledge of the genetic composition of Physcomitrella and Sphagnum mosses. Smart breeding allows obtaining fast-growing peat mosses in suitable amounts for paludicultures. Project partners are also the Karlsruhe Institute of Technology and a company from Lower Saxony. The German Federal Ministry of Food and Agriculture (BMEL) is funding the project with approx. 1.1 million Euros for the next 3 years.

media release at the University of Freiburg

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16 March 2017 · Applied research · Media Release

Milestone Achieved: From Moss into Man

Greenovation Biotech GmbH announced that it has dosed the first patient in a phase 1b study of its biopharmaceutical, moss-aGal, in adults with the inherited disorder, Fabry disease. Moss-aGal is a recombinant form of human alpha-galactosidase. It has been developed by Greenovation as an enzyme replacement therapy (ERT) for patients with Fabry disease, a genetic lysosomal storage disorder.  The privately owned company Greenovation was founded by Prof. Dr. Gunter Neuhaus and Prof. Dr. Ralf Reski and develops next-generation therapeutics using its proprietary BryoTechnology platform. The company aims to optimize the production of highly-efficient glycoproteins for proprietary and customer use.

whole media release at Greenovation

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08 March 2017 · Basic research · Media Release

The Protective Layer of Prehistoric Land Plants

Mosses cover a tree. An international research team has discovered a pathway with which these tiny plants produce their outer protective layer. Photo: Ralf Reski.

An international research team has discovered a mechanism in mosses that was crucial for the evolution of ecosystems on land. They discovered a biochemical pathway that is responsible for the development of cuticles in the moss Physcomitrella patens. These waxy coverings of epidermal cells are the outer layer of plants and protect them from water loss. In the Journal Nature Communications the biologists describe that the enzyme CYP98 from the family of cytochromes P450 is responsible for the development of a phenol-enriched cuticle in Physcomitrella whereas it is known to initiate the production of lignin in seed plants. Plant cuticles came into being more than 450 million years ago when the first plants colonized the hitherto hostile landmasses. Because the waxy cuticles protect against water loss, they enabled the spread of plants on land and the subsequent evolution of our complex ecosystems. The research team was led by Professor Ralf Reski from the University of Freiburg/Germany and Doctor Danièle Werck-Reichhart from the Centre National de la Recherche Scientifique (CNRS) Institute of Plant Molecular Biology (IBMP) in Strasbourg/France. The results also suggest new biotechnology strategies for engineering biopolymers in plants beyond the well-known lignin production of trees.

media release at the University of Freiburg 

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13 January 2017 · Basic research · Media Release

Survival Artists in the Antarctic

Moss researcher Hyoungseok Lee in Antarctica. Photo: KOPRI

Improve our understanding of the impact climate change on plant life in the Antarctic is a new research project in the ReskiLab. Biologists Prof. Dr. Ralf Reski from the University of Freiburg, Germany, and Dr. Hyoungseok Lee from the Korea Polar Research Institute KOPRI, South Korea, will join forces to decipher the genome of an Antarctic strain of the moss Sanionia uncinata. In a second step the genome will be compared to the genome of the model moss Physcomitrella patens, which cannot grow in Antarctica. The project will be funded by KOPRI’s “Polar Genomes 101 Project”. “We are excited about this new opportunity and expect new insights into plant adaptation to harsh environmental conditions,” says Reski. Therefore the Rector of the University of Freiburg/Germany, Prof. Dr. Hans-Jochen Schiewer, and the President of the Korea Polar Research Institute KOPRI, Dr. Ho-Il Yoon, have just signed a co-operation agreement on moss research.

media release at the University of Freiburg

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28 November 2016 · Basic research · Media Release

Biologists Discover Origin of Stomata

Fluorescence microscope image of Physcomitrella moss cells showing two stomata (fluorescing in green) and the chlorophyll of the chloroplasts (fluorescing in red). Photo: Dr. Stefanie Mueller

An international team has discovered a genetic mechanism that is responsible for the development of stomata – microscopic valves on the surface of plants that facilitate the uptake of carbon dioxide and the release of oxygen and water vapor. The researchers discovered this mechanism, which was previously known in flowering plants like Arabidopsis thaliana, in the moss Physcomitrella patens and found similarities between the two, implying that it already existed in the last common ancestor of mosses and flowering plants. The team was led by the biologists Professor Ralf Reski from the University of Freiburg/Germany and Professor David J. Beerling from the University of Sheffield/UK. The results were published in the journal Nature Plants.

media release at the University of Freiburg

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14 April 2016 · Basic research · Media Release

How to get rid of proteins

Scientists of the Reski lab discover substrates for targeted protein degradation. A German team led by the Freiburg-based biologist Professor Ralf Reski has discovered substrates and interaction partners of the so-called N-end rule pathway of protein degradation in the moss Physcomitrella patens. The study is published in the journal Molecular and Cellular Proteomics.

media release at the University of Freiburg

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17 February 2016 · Applied research · Media Release

Towards a moss-based expression system

New data provides validation for Greenovation’s moss-based expression system as a GMP-compliant biopharmaceutical production system - successful collaboration with BioGenes.

  • Novel Physcomitrella patens-specific host-cell protein assay developed for GMP-compliant production in moss.
  • New data published in BioProcess International, February 2016

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18 January 2016 · Basic research · Media Release

No sex required

A German-Israeli team led by the biologists Professor Ralf Reski from Freiburg and Professor Nir Ohad from Tel-Aviv has discovered a gene trigger in the moss Physcomitrella patens which leads to offspring without fertilization. The researchers assume that this mechanism is conserved in evolution and holds the key to answer fundamental questions in biology. The study is published in the journal Nature Plants.

Whole media release at the University of Freiburg

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22 December 2015 · Applied research · Media Release

FRIAS-USIAS Alumnus Ralf Reski has cultivated peat moss for measuring air quality

Prof. Dr. Ralf Reski, professor for biology and former FRIAS-USIAS Fellow, together with 30 experts at five universities and five medium-sized companies from Spain, Italy, France, Ireland and Germany, set out to develop a form of “biomonitoring” that is independent of electricity and mobile with the help of peat moss. Within only three years, the consortium MOSSclone, which is funded by the EU’s “Eco-Innovation!” programme, has been able to cultivate a type of moss that allows for the measurement of not only nitrogen and sulfur oxides or heavy metal concentrations, but also polycyclic aromatic hydrocarbons, most of which are carcinogenic.

see: Freiburg Institute for Advanced Studies (FRIAS) at Albert-Ludwigs-Universität Freiburg

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12 August 2015 · Media Release · Teaching

New curricula for a valuable resource

The European Union supports international project for the sustainable usage of water with almost one million euros, called TREASURE WATER

read whole text at the University of Freiburg website

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30 March 2015 · Applied research · Media Release

From Moss to Mouse

University of Freiburg to cooperate with a biopharmaceutical company on therapy for kidney diseases

read more at University of Freiburg

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15 September 2014 · Basic research · Media Release

Mosses survive climate catastrophes

German scientists discover why these plants endured ice ages.

read whole text at the University of Freiburg website

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12 February 2014 · Media Release

Engineering moss for biopolymer and biofuel production

An international research team emerges as a FRIAS/USIAS partnership in Freiburg and Strasbourg

read whole media release about the new research partnership published by FRIAS

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23 September 2013 · Applied research · Media Release

Halftime for mosses as measuring devices

An international research team takes stock on their way to monitoring air quality in Europe. The team meets at the Freiburg Institute for Advanced Studies (FRIAS).

read whole text at University of Freiburg website

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21 August 2013 · Applied research · Media Release

Research with the Moss Bioreactor

University of Freiburg and greenovation Biotech to cooperate on improved product yields.

read whole text at the University of Freiburg website

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05 August 2013 · Basic research · Media Release

Moss beats Human

A group of German, Belgian and Japanese scientists, coordinated by Professor Ralf Reski from the University of Freiburg, Germany, published a new study in the journal BMC Genomics where they describe 32,275 protein-encoding genes from the moss Physcomitrella patens. This is about 10,000 genes more than the human genome contains.

read whole text at the University of Freiburg website

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04 July 2013 · Applied research · Basic research · Media Release

Freiburg and Strasbourg join forces

Joint research groups of Freiburg Institute for Advanced Studies (FRIAS) and University of Strasbourg Institute for Advanced Study (USIAS).

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06 May 2013 · Applied research · Media Release

Greenovation Biotech and Biomeva cooperate

greenovation Biotech GmbH and Biomeva GmbH sign development, manufacturing and supply agreement for GMP production of a protein with a novel expression platform.

read whole text at Biomeva (pdf file)

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03 August 2012 · Event · Media Release

Think globally, act locally

International scientists discuss possible societal benefits of plant research in Freiburg. Focal point of more than 600 scientific contributions of the Plant Biology Congress was the question of how researchers can apply their results to benefit society.

read whole text at the University of Freiburg website

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21 June 2012 · Event · Media Release

All Set for "Green" - Plant Biology Congress Freiburg

The University of Freiburg is awaiting 1,000 plant researchers who will come together for the Plant Biology Congress Freiburg 2012, which is organized by Professors Heinz Rennenberg and Ralf Reski.

read whole text at the University of Freiburg website

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01 June 2012 · Applied research · Media Release

EPO for the Brain

Engineered Moss produces human hormone without doping activity.  Scientists from the Chair of Plant Biotechnology of the University of Freiburg, Germany, around Dr. Eva Decker and Professor Ralf Reski and from the Freiburg-based biotech company greenovation have genetically engineered the moss Physcomitrella patens in such a way that it now produces recombinant human asialo-EPO in the moss bioreactor and published their results in the Plant Biotechnology Journal.

read whole text at the University of Freiburg website

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08 May 2012 · Media Release

BIOPRO Baden-Württemberg: 10 years

More than 120 invited guests came to Stuttgart on 2 May 2012 to discuss the potential of biotechnology in Baden-Württemberg – and to celebrate! Prof. Ralf Reski from the University of Freiburg was the second to congratulate BIOPRO on their success, after the speach of Wolfgang Leidig, head of department in the Baden-Württemberg Ministry of Finance and Economic Affairs.

read whole text at BIOPRO

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03 April 2012 · Applied research · Media Release

Moss detects Air Pollution

EU-Project develops peat moss as novel biological indicator with the help of the ReskiLab.

read whole text at the University of Freiburg website

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07 December 2011 · Applied research · Media Release

Moss well invested

Contract between Freiburg Biobank of Plant Biotechnology (International Moss Stock Center, IMSC) and Greenovation Biotech GmbH.

read whole text at the University of Freiburg website

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14 December 2010 · Media Release

No Phenylketonuria in the Moss Physcomitrella patens

International Team Discovers New Metabolic Pathway.

read whole text at the University of Freiburg website

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18 March 2010 · Event · Media Release

Freiburg welcomes historic plant meeting

Largest European Congress for Plant Science to be held at the University of Freiburg, Germany, in 2012. Prof. Dr. Heinz Rennenberg (Faculty of Forest and Environmental Sciences) and Prof. Dr. Ralf Reski (Faculty of Biology) will organise the meeting.

read whole text at the University of Freiburg website

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24 February 2010 · Media Release

Mosses, deep-frozen

The University of Freiburg, Germany, launches a new resource centre, the International Moss Stock Center (IMSC).

read whole text at the University of Freiburg website

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08 January 2010 · Basic research · Media Release

Micro RNAs make Genes shut up

German Researchers have discovered a Novel Mechanism for Gene Regulation - Publication in the journal Cell.

read whole text at the University of Freiburg website

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06 May 2009 · Applied research · Media Release

Biotechnology: Moss can produce human proteins

Mosses and humans share unexpected common characteristics researchers from ETH Zurich and University of Freiburg have shown in the Plant Biotechnology Journal. These evolutionary relics could be useful in the production of therapeutic proteins.

read whole text of the ETH Zürich

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04 April 2008 · Applied research · Media Release

BMBF sponsors consortium on gene targeting

The GABI-PRECISE consortium announces cooperation for the development of precision engineering of genes, in which the ReskiLab is one of the collaborators.

read whole text at Phytowelt

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13 December 2007 · Basic research · Media Release

How plants conquered the land

Biologists at University of Freiburg play a leading role in deciphering the moss genome.

read whole text of University of Freiburg 

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04 October 2006 · Applied research · Media Release

Joint Project on Molecular Farming in Moss Bioreactor Granted

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26 August 2004 · Basic research · Media Release

Moss genome sequencing granted

The Washington University in St. Louis reports about the genome sequencing in the moss Physcomitrella patens.

more at Washington University in St. Louis website

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26 April 2004 · Media Release

Start your career in biology at University of Freiburg

Personnel managers from big German companies: Start your career in biology at University of Freiburg

read whole text at the University of Freiburg website

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21 December 1998 · Media Release

BASF and Freiburg University to collaborate on plant biotechnology

The Albert-Ludwig University of Freiburg, BASF Aktiengesellschaft, Ludwigshafen, and private lecturer Dr. Ralf Reski have concluded a cooperation agreement in the field of plant biotechnology. The object of this scientific collaboration is to elucidate the biological function of plant genes. The cooperation will involve expenditures of more than DM 30 million over the next four years. BASF will finance the salaries and operating inputs for 40 scientists and laboratory technicians. Freiburg University will provide the laboratory building and the infrastructure required for operating the laboratories.

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